Buffalo scored first on a R. Davis 1-yard rush at 9:32 of the first quarter, but Cleveland answered before the period ended when S. Sanders found Floriea on an 8-yard pass to tie it at seven. The Bills then scored on four straight possessions to close the game out. Hardman hauled in a 9-yard pass from K. Allen just before halftime to make it 14-7, and in the third quarter Bass converted a 52-yard field goal before Buechele connected with Maclin on a 71-yard strike to push the lead to 24-7. Buechele then added a 5-yard rushing touchdown in the fourth to set the final score.

With no standings or bracket at stake, the headline from a Bills perspective is the performance of Buechele, who finished 5-of-10 for 111 yards and a passing touchdown to go with a rushing score. Maclin was the standout receiver, turning two catches into 108 yards including the 71-yard touchdown. For Cleveland, Sanders completed 9 of 11 passes for 74 yards and a score but also threw an interception, with the Browns' offense going scoreless after the first quarter.